Supercritical Fluid Chromatography System
(with optional supercritical fluid extraction capabilities)
Supercritical fluid chromatography (SFC) is a separation method that uses supercritical CO2 as the mobile phase. The benefits of supercritical CO2 are the low polarity similar to n-hexane, the lower viscosity, and the high diffusion coefficient, which offers potential advanced separation methods that are different from conventional HPLC separation. Thanks to this feature, SFC enables unique analyses, such as high resolution chromatography, simultaneous analysis of compounds over a wide polarity range, and improvement of MS detection sensitivity.
Key Features
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Higher Resolution
- The analysis time can be effectively shortened because an excellent chromatographic resolution can be maintained even at higher flow rates than those typically used for HPLC.
Available for Both UHPLC and SFC Analysis Using a Single System
- Separation results can be quickly obtained during method development by screening with both SFC and UHPLC.
Nexera Analytical SFC Reduces Environmental Impact
- Up to 4 different rinsing solutions
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Small Volume Fractionation
- By using a fraction collector, small-volume fractionation is also possible (ex: 96 well MTP’s.)
Fully Automated On-Line Extraction and Separation
- Target compounds are extracted from solid samples, and then automatically transferred to SFC.
Nexera Analytical SFC Reduces Environmental Impact
- By using SFC, the consumption of organic solvent is reduced by 94.2%, compared to the normal-phase.
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