8045 – LC-MS/MS

LCMS-8045 Triple Quadrupole Liquid Chromatograph Mass Spectrometer (LC-MS/MS)

The triple quadrupole LCMS-8045 is the workhorse instrument in the Shimadzu LC-MS/MS lineup, designed for around-the-clock sample analyses. The heated ESI probe, high-temperature heating block, heated desolvation line, drying gas, and focusing optics all act to maximize sensitivity while minimizing contamination, resulting in continuous operation in the laboratory with reliable data collection, even for complex matrices like biological fluids or foods.

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Key Features

  • High Sensitivity and Ultra-High-Speed Detection

    Superior Robustness

    • Assures that high sensitivity is maintained over the long term
  • LabSolutions Software

    • Designed for specific workflows


  • Model

    • LCMS-8045

    Mass Range

    • m/z 2 to 2,000


    • ESI positive:
      1 pg reserpine, S/N > 100,000:1 (RMS)
    • ESI negative:
      1 pg chloramphenicol, S/N > 100,000:1 (RMS)


    • R < 0.7 u FWHM


    • < 0.003 %

    Minimum Pause Time

    • 1 msec

    Minimum Dwell Time

    • 0.8 msec

    Scan Speed

    • Max 30,000 u/sec (in all modes of scanning)
      (0.1 u step: 300,000 data points/sec)

    Block heater Maximum Temperature

    • ESI/DUIS: 500° C
    • APCI: 300° C

    Interface Maximum Settable Temperature

    • ESI/DUIS: 400° C
    • APCI: 500° C
  • Mass Stability

    • 0.05 u/12 hr

    Polarity Switching Time

    • 5 msec


    • ESI (Standard)
    • APCI (Optional)
    • DUIS (Optional)

    Applicable LC Flow Rate

    • ESI 1 μL/min to 2 mL/min

    MRM Transition Speed

    • Max 555 channels/sec

    DL Maximum Temperature

    • 300° C

    Analysis Mode

    • 1 Scan/SIM
    • Q3 Scan/SIM
    • Precursor ion scan
    • Product ion scan
    • Neutral loss scan

Application Versatile

  • Easy Operation/Maintenance

    • Quickly and easily replace the DL without breaking vacuum, providing greater uptime and usability
  • Superior Robustness

    • No cable or tubes and no tools are needed to detach the needles fitted in APCI and DUIS units

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