8050 – LC-MS/MS

High-Sensitivity & High-Speed Scanning at 30,000 u/sec

Enhancements in chromatography and sub-2 micron columns have resulted in narrower peak widths, thereby increasing resolution. Analysts are demanding shorter chromatographic run times while adding more analyses to a single method. With these two factors at play, it is clear that the LCMS-8050’s ultra-fast mass spectrometer can accurately and reliably detect each compound in a sample.

The LCMS-8050 is capable of simultaneously obtaining both qualitative and quantitative information in a single analysis. Rapid acquisition allows MS/MS scans and MRM measurements to be performed concurrently while maintaining quantitative accuracy. MS/MS scans are usable and reliable because even at 30,000 u/sec, Shimadzu uses a 0.1 u scan step.

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Specifications

Model
LCMS-8050
Mass range
m/z 2 to 2,000
Sensitivity
ESI positive:
1 pg reserpine, S/N > 250,000:1 (RMS)
ESI negative:
1 pg chloramphenicol, S/N > 250,000:1 (RMS)
Resolution
R < 0.7 u FWHM
Mass stability
0.1 u / 24 hr
Mass accuracy
±0.15 u or less (m/z 1,000)
Cross-talk
< 0.003 %
Minimum pause time
1 msec
Minimum dwell time
0.8 msec
Scan speed
Max 30,000 u/sec (in all modes of scanning)
(0.1 u step: 300,000 data points/sec)
Polarity switching time
5 msec
Interface
ESI (Standard),
APCI (Optional), DUIS (Optional)
Applicable LC flow rate
ESI 1 μL/min to 2 mL/min
MRM transition speed
Max 555 channels/sec
DL maximum temperature
300 °C
Block heater maximum temperature
ESI/DUIS: 500 °C
APCI: 300 °C
Interface maximum settable temperature
ESI/DUIS: 400 °C
APCI: 500 °C
Analysis mode
Q1 Scan/SIM
Q3 Scan/SIM
MRM
Precursor ion scan
Product ion scan
Neutral loss scan
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Features & Benefits

  • Unmatched speed & sensitivity
  • Simultaneous collection of multiple MRM events with full scan product ion spectra at different collision energies

Technology. UF-Qarray: The innovative design of the Qarray allows for enhancement of ion signal while simultaneously reducing noise. This yields ultra-low detection limits, allowing for trace quantitation

Fast polarity switching.  uses UF Technologies to switch polarity in 5 ms

Detection. Fast cycle time helps to detect more compounds with greater confidence and precision

Easy Operation/Maintenance.  Quickly and easily replace the DL without breaking vacuum, providing greater uptime and usability

Newly Designed Ionization Unit. No cable or tubes and no tools are needed to detach the needles fitted in APCI and DUIS units